Butternut Squash and Spinach Lasagna

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Looking for the best vegetarian lasagna recipe? You're in the right place. This Butternut Squash and Spinach lasagna will become one of your favorites!  This lasagna is stuffed with vegetables and combines Ricotta, Parmesan, and Mozzarella cheeses to create the ultimate Fall and Winter comfort food.

This delicious veggie lasagna recipe is healthy, meatless, gluten-free friendly, and perfect for the Fall and Winter season.   Because it uses butternut squash, it's a great choice as a holiday vegetarian main dish or just a holiday recipe.    It's so good, it's popular with kids!

To me, this is a great recipe to make any time of year, but because this lasagna has butternut squash, it is surely a good holiday veggie main dish for Thanksgiving, Christmas, or New Year's Eve.

This vegetarian recipe uses butternut squash puree, which you can easily make by following my easy step-by-step tutorial: how to make butternut squash puree. Or, you can always buy pureed butternut squash at the store.

I also want to warn you that this is my most photo-intensive post yet with lots of step-by-step photos which I think are quite helpful to make this delicious vegetarian lasagna. So, if you want to go directly to the bottom of this post - just scroll down.

Cooking tips

• Use cooked lasagna noodles. Bring a large pot of water to boil, cook the noodles al dente, rinse each noodle with cold water and drain. This will guarantee the perfect texture!
• Make this vegetarian lasagna gluten-free! Use brown rice gluten-free lasagna noodles and follow all the recipe instructions as-is.
• For butternut squash filling, make your own butternut squash puree from scratch or use a store-bought version.
• Here is a great tutorial on how to cook fresh spinach - this recipe uses lemon juice and lemon juice which will pair well with the butternut squash, but you can also skip the lemon and/or lemon zest if you don't like it.
• No boil lasagna noodles.  You can use no-boil lasagna noodles with this recipe!  You might need to add about ½ cup of milk or water or vegetable stock to the squash purée, in addition to the milk called for in the recipe.  (Thank you, Debbie, for your great tip!)  You might also have to bake the lasagna for 10 extra minutes.
• Make this lasagna vegan.  Use vegan Parmesan and Mozzarella cheeses, then make vegan ricotta out of tofu and lemon juice using this recipe.  (Thank you, Laura, for this wonderful tip!)
• Don't like vegetarian and want protein or meat?  No problem.  Add rotisserie chicken or cooked crumbled bacon in between lasagna layers.

I also tested this butternut squash and spinach lasagna with gluten-free noodles, and it works great! I used Tinkyada gluten-free brown rice lasagna noodles - almost the whole 10 oz package.  So, yes, this recipe is gluten-free friendly, for sure!

Bake this vegetarian lasagna at 375 F covered with foil for the first 30 minutes, then remove foil and bake for additional 10 minutes.

With this delicious meatless vegetable lasagna, you will have no leftovers!

How to make vegetarian butternut squash and spinach lasagna (step-by-step photos):

First, prepare the butternut squash filling. Using a food processor, combine butternut squash puree with Ricotta cheese, milk, salt, and nutmeg. Add more milk if needed (to make the butternut squash filling very creamy).  Mix very well, taste, and add more salt, if needed:

Next, make spinach filling by mixing cooked spinach, Ricotta cheese, Mozzarella cheese, minced garlic, salt and pepper:

Prepare a baking dish - I used a casserole dish 11 inches x 8.5 inches x 3 inches deep. Grease the bottom of the baking pan lightly with olive oil spray. Spread ⅓ of butternut squash filling on the bottom of the dish. Sprinkle lightly with mozzarella cheese.

Cook the lasagna noodles according to the package instructions, rinse with cold water and drain. Top the first layer of butternut squash mixture with cooked lasagna noodles without overlapping - as you can see I used 3 noodles. Use as many noodles as you need for your baking dish.

Spread half of spinach filling over the cooked noodles.

Top lightly with Mozzarella cheese:

Top with cooked lasagna noodles:

Spread another layer (⅓) of butternut squash mixture:

Sprinkle lightly with Mozzarella cheese:

Top with cooked lasagna noodles:

Spread the remaining half of spinach filling over the noodles. Top lightly with Mozzarella cheese.

Top with the final layer of cooked noodles:

Spread a generous amount of butternut squash filling (the remaining ⅓) over this final layer of noodles:

Sprinkle with grated Parmesan and remaining Mozzarella cheese (about ½ cup of Mozzarella):

Generously sprinkle the cheese with Italian seasoning, paprika, basil:

Cover the baking dish with foil and bake for 30 min. Remove foil and bake additional 10 minutes.

Your veggie lasagna is ready!

Recipes with Butternut Squash

Since you're looking at this butternut squash and spinach lasagna, I assume you like butternut squash. Here are a few other delicious recipes using this wonderful ingredient.  All these recipes are also vegetarian and meatless.

• Butternut Squash and Spinach Tortellini
• Roasted Brussels Sprouts, Cinnamon Butternut Squash, Pecans, and Cranberries
• Black Bean and Butternut Squash Enchilada Casserole
• Quinoa Salad with Butternut Squash, Pine Nuts, Caramelized Onions and Feta cheese

Butternut Squash Salads:

• Autumn Salad with Butternut Squash and Pumpkin Seeds
• Butternut Squash Salad with Spinach, Pecans, Cranberries, and Pomegranate

4.73 from 864 votes

Butternut Squash and Spinach Lasagna

Delicious vegetarian lasagna recipe that uses vegetables (butternut squash, spinach), and three cheeses (Ricotta, Mozzarella, and Parmesan)!   Perfect as a veggie main dish for every day.  Healthier version of lasagna.  Also, a great holiday recipe for Thanksgiving or Christmas! 

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Prep Time 30 minutes mins

Cook Time 40 minutes mins

Total Time 1 hour hr 10 minutes mins

Course Main Course

Cuisine American, Italian

Servings 8 servings

Calories per serving 401 kcal

Author: Julia

Ingredients

Butternut Squash Filling:

• 2 cups butternut squash puree (about half of squash)
• 1 cup ricotta cheese
• ½ cup milk or more, if needed
• ¼ teaspoon salt plus ⅛ teaspoon more
• ¼ teaspoon nutmeg

Spinach Filling:

• 8 oz spinach (1 cup cooked spinach)
• 1 cup ricotta cheese
• 1 cup mozzarella cheese
• 2 garlic cloves minced
• ¼ teaspoon salt
• pepper to taste

Other Ingredients:

• 10 oz lasagna noodles cooked (for gluten free, use Tinkyada brown rice lasagna noodles)
• 1 ½ cups mozzarella cheese or more
• ½ cup Parmesan cheese on top
• ¼ teaspoon Italian seasoning
• ¼ teaspoon Paprika
• ¼ teaspoon Basil

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Instructions 

• Preheat oven to 375 F.

Butternut Squash Filling:

• For this filling, you will need to have pre-cooked butternut squash puree. Using food processor, combine 2 cups of butternut squash puree with Ricotta cheese, milk, salt and nutmeg. Add more milk if needed (to make the butternut squash filling very creamy). Mix very well, taste and add more salt, if needed.
  

Spinach Filling:

• Combine cooked spinach, Ricotta cheese, mozzarella, garlic, salt and pepper. Mix, taste, and add more salt and pepper, if needed.
• Note: The recipe I provide for how to cook spinach uses lemon juice and lemon zest which pairs nicely with butternut squash but you don't have to use lemon juice and/or lemon zest if you don't like it.

Cooking lasagna noodles:

• Bring a very large pot of water to boil, and cook lasagna noodles according to package instructions. Rinse in cold water, drain. Using knife, trim noodles to fit your baking dish (if necessary).

How to assemble vegetarian lasagna:

• Prepare a baking dish - I used a casserole dish 11 inches x 8.5 inches x 3 inches deep. Grease the lasagna dish lightly with olive oil spray. Spread ⅓ of butternut squash filling on the bottom of the dish. Sprinkle lightly with mozzarella cheese. Top with cooked lasagna noodles without overlapping (I used 3 noodles).
• Spread half of spinach filling over the noodles. Top lightly with Mozzarella cheese. Top with cooked noodles.
• Spread another layer (⅓) of butternut squash mixture, then sprinkle lightly with Mozzarella cheese. Top with cooked noodles.
• Spread the remaining half of spinach filling over the noodles. Top lightly with Mozzarella cheese. Top with the final layer of cooked noodles.
• Spread a generous amount of butternut squash filling (the remaining ⅓) over this final layer of noodles, sprinkle with grated Parmesan and remaining mozzarella cheese (about ½ cup of mozzarella). Generously sprinkle the cheese with Italian seasoning, paprika, basil.
• Cover the baking dish with foil and bake for 30 min. Remove foil and bake additional 10 minutes.

Notes

Make it GLUTEN-FREE

• Use brown rice gluten-free lasagna noodles (or any other kind of GF lasagna noodles) and follow all the recipe instructions as-is.

How to use NO-BOIL LASAGNA NOODLES

• You can use no-boil lasagna noodles with this recipe!  You might need to add about ½ cup of milk or water or vegetable stock to the squash purée, in addition to the milk called for in the recipe.  (Thank you, Debbie, for your great tip!)  You might also have to bake the lasagna for 10 extra minutes.

How to make it VEGAN

• Use vegan Parmesan and Mozzarella cheeses, then make vegan ricotta out of tofu and lemon juice using this recipe.  (Thank you, Laura, for this wonderful tip!)

Nutrition

Nutrition Information

Butternut Squash and Spinach Lasagna

Amount per Serving

Calories

401

% Daily Value*

Fat

 

18

g

28

%

Saturated Fat

 

11

g

69

%

Cholesterol

 

64

mg

21

%

Sodium

 

549

mg

24

%

Potassium

 

477

mg

14

%

Carbohydrates

 

35

g

12

%

Fiber

 

2

g

8

%

Sugar

 

3

g

3

%

Protein

 

23

g

46

%

Vitamin A

 

6995

IU

140

%

Vitamin C

 

15.5

mg

19

%

Calcium

 

449

mg

45

%

Iron

 

1.9

mg

11

%

* Percent Daily Values are based on a 2000 calorie diet.

Nutrition Disclaimer:

The nutritional information on this website is only an estimate and is provided for convenience and as a courtesy only. The accuracy of the nutritional information for any recipe on this site is not guaranteed. It should not be used as a substitute for a professional nutritionist’s advice.

Keyword butternut squash lasagna, vegetarian lasagna